NEUROPATHY RESEARCH
Novel Magnetic Pulse Therapy Device Reduces Diabetic Neuropathic Foot Pain by Over 77%
In a pilot study led byKashif M. Munir, MD, associate professor of medicine at the University of Maryland School of Medicine and medical director at the UM Center for Diabetes and Endocrinology, a single TCMS treatment session reduced mean self-reported pain scores by 77.7 percent immediately post-treatment.
Pulsed Magnetic Field Therapy in Refractory Neuropathic Pain Secondary to Peripheral Neuropathy: Electrodiagnostic Parameters—Pilot Study
(Link: https://journals.sagepub.com/doi/10.1177/0888439003261024)
All 24 feet completed 9 days of treatment. 15/24 completed follow-up (62%) with mean pain scores decreasing 21% from baseline to end of treatment (P= 0.19) but with 49% reduction of pain scores from baseline to end of follow-up (P< 0.01). Of this group, self-reported PGIC was improved 67% (n = 10) and no change was 33% (n = 5). An intent-to-treat analysis based on all 24 feet demonstrated a 19% reduction in pain scores from baseline to end of treatment (P= 0.10) and a 37% decrease from baseline to end of follow-up.
The Change of HCN1/HCN2 mRNA Expression in Peripheral Nerve After Chronic Constriction Injury Induced Neuropathy Followed by Pulsed Electromagnetic Field Therapy
(Link: https://pubmed.ncbi.nlm.nih.gov/27901476/)
Neuropathic pain is usually defined as a chronic pain state caused by peripheral or central nerve injury as a result of acute damage or systemic diseases. It remains a difficult disease to treat.
Recent studies showed that the frequency of action potentials in nociceptive afferents is affected by the activity of hyperpolarization-activated cyclic nucleotide-gated cation channels (HCN) family. In the current study, we used a neuropathy rat model induced by chronic constriction injury (CCI) of sciatic nerve to evaluate the change of expression of HCN1/HCN2 mRNA in peripheral nerve and spinal cord.
Rats were subjected to CCI with or without pulsed electromagnetic field (PEMF) therapy. It was found that CCI induced neural cell degeneration while PEMF promoted nerve regeneration as documented by Nissl staining. CCI shortened the hind paw withdrawal latency (PWL) and hind paw withdrawal threshold (PWT) and PEMF prolonged the PWL and PWT. In addition, CCI lowers the expression of HCN1 and HCN2 mRNA and PEMF cannot restore the expression of HCN1 and HCN2 mRNA. Our results indicated that PEMF can promote nerve regeneration and could be used for the treatment of neuropathic pain.